THE ULTIMATE GUIDE TO METHADONE REHAB CENTERS

[sixty one] Like several other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with various potency. Dextromethadone, and that is a lot less potent as an opioid, is a lot more strong at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone incorporates a lower affinity, with